Vesiderm Liposomes

The new differentiator in skincare

Vesiderm Liposomes are made using yolk lecithin, a well-known health supplement and a rich source of essential fats and fat-soluble micronutrients that are functionally critical for our brain, heart, liver and skin.  Vesiderm technology efficiently organised these essential fats and micronutrients into tiny nanosized liposomes with a central water core.    These features enable fats and fat-soluble nutrients to be easily delivered to cells in our body.  In fact, Mother-nature has been using liposome-like structures such as exosomes for many important functions – cell-to-cell delivery or communication vehicles.  Like exosomes, liposomes can readily penetrate the skin or be taken up by cells to deliver lipids and micronutrients.  Vesiderm liposomes have been shown to improve the vitality of human skin and stem cells, and enhance collagen production by human skin cells.

How Vesiderm Yolk Lecithin Liposomes gives you healthy skin

Vesiderm uses egg yolk lecithin because egg yolk lecithin are enriched in human skin lipid precursors, and micronutrients.  Importantly, egg yolk lecithin is classified as Generally Regarded As Safe (GRAS) by the US FDA, and have a long safety track record as additives in many pharmaceutical preparations.

Anatomy of our skin

The skin is the single largest organ in our body, acting as a barrier that protects our body from the harsh elements of the outside world.

Skin has three layers:

  • Epidermis.

The epidermis is the outermost layer of skin, provides a waterproof barrier and creates our skin tone. It is composed primarily of cells known as keratinocytes.

  • Dermis

The dermis which is beneath the epidermis, contains tough connective tissue, hair follicles, and sweat glands.

  • Hypodermis

The deeper subcutaneous tissue (hypodermis) is made of fat and connective tissue.

Commercial Page 1
Commercial Page 2

Let’s take a close look at the Function and Importance of the Epidermis.

The epidermis is the outermost layer of our skin. The cellular structure of the epidermis also forms a highly renewable and effective barrier against germs. When skin is healthy and intact, it is difficult for bacteria and viruses to make an entrance.  It also prevents fluid loss from our body.

Layers of the Epidermis

Depending on the location in our body, the epidermis is composed of four or five main strata, or layers, namely the Stratum Corneum, Stratum Lucidum, Stratum Granulosum, Stratum Spinosum and Stratum Basale.

The top layer of epidermis, Stratum Corneum consists of dead keratinocytes known as corneocytes.  These corneocytes are constantly being sloughed off from normal wear and tear.  To maintain this outermost layer, these corneocytes must be replaced as rapidly as they are sloughed off.

Keratinocytes are produced in the Stratum Basale which is the lowest layer of the epidermis.  These keratinocytes then migrate upward towards the Stratum Corneum through the Stratum Spinosum, then Stratum Granulosum (and sometime the Stratum Lucidum) before reaching its final destination, the Stratum Corneum.  As the keratinocytes migrate, they differentiate before dying to form tightly linked protein-filled corneocytes with dense protein envelope.   

Commercial Page 3
Commercial Page 4

Relevance of liposomes to skin health (2)

• Skin Barrier
– Composed of lipid bilayers in SC extracellular space
– Daily loss of stratum corneum lipids = 40-80 mg
• Not compensated by synthesis in older skins

• Depletion → xerosis (dry skin)
Schurer, N.Y. and P.M. Elias, The biochemistry and function of stratum corneum lipids. Adv Lipid Res, 1991. 24: p. 27-56
• 40–50% ceramides

• 25% cholesterol

• 10–15% fatty acids
– SC lipids are produced from enzymatic hydrolysis of precursors in the SC

Commercial Page 5

Are you a retailer, wholesaler, or skincare company looking to expand your range of products?

Get in touch with our commercial team to discuss further.